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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
Hooftman, Alexander; Peace, Christian G; Ryan, Dylan G; Day, Emily A; Yang, Ming; McGettrick, Anne F; Yin, Maureen; Montano, Erica N; Huo, Lihong; Toller-Kawahisa, Juliana E; Zecchini, Vincent; Ryan, Tristram A J; Bolado-Carrancio, Alfonso; Casey, Alva M; Prag, Hiran A; Costa, Ana S H; De Los Santos, Gabriela; Ishimori, Mariko; Wallace, Daniel J; Venuturupalli, Swamy; Nikitopoulou, Efterpi; Frizzell, Norma; Johansson, Cecilia; Von Kriegsheim, Alexander; Murphy, Michael P; Jefferies, Caroline; Frezza, Christian; O'Neill, Luke A J.
Affiliation
  • Hooftman A; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. ahooftma@tcd.ie.
  • Peace CG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Ryan DG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. dr523@cam.ac.uk.
  • Day EA; MRC Cancer Unit, University of Cambridge, Cambridge, UK. dr523@cam.ac.uk.
  • Yang M; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. dr523@cam.ac.uk.
  • McGettrick AF; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Yin M; MRC Cancer Unit, University of Cambridge, Cambridge, UK.
  • Montano EN; CECAD Research Centre, Faculty of Medicine, University of Cologne, Cologne, Germany.
  • Huo L; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Toller-Kawahisa JE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Zecchini V; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Ryan TAJ; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Bolado-Carrancio A; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Casey AM; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Prag HA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Costa ASH; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.
  • De Los Santos G; MRC Cancer Unit, University of Cambridge, Cambridge, UK.
  • Ishimori M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Wallace DJ; Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK.
  • Venuturupalli S; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Nikitopoulou E; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Frizzell N; MRC Cancer Unit, University of Cambridge, Cambridge, UK.
  • Johansson C; Matterworks, Somerville, MA, USA.
  • Von Kriegsheim A; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Murphy MP; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • Jefferies C; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Frezza C; Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • O'Neill LAJ; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Nature ; 615(7952): 490-498, 2023 03.
Article in En | MEDLINE | ID: mdl-36890227
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-beta / RNA, Mitochondrial / Fumarate Hydratase / Macrophages / Mitochondria Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nature Year: 2023 Document type: Article Affiliation country: Irlanda Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-beta / RNA, Mitochondrial / Fumarate Hydratase / Macrophages / Mitochondria Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nature Year: 2023 Document type: Article Affiliation country: Irlanda Country of publication: Reino Unido