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Highly diastereo- and enantioselective C2 addition of 5H-oxazol-4-ones to γ-keto-α,ß-unsaturated esters.
Lin, Li; Wang, Mei; Zhou, Jiawei; Li, Fei; Liu, Huiyun.
Affiliation
  • Lin L; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. linli@lzu.edu.cn
  • Wang M; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. linli@lzu.edu.cn
  • Zhou J; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. linli@lzu.edu.cn
  • Li F; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. linli@lzu.edu.cn
  • Liu H; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P. R. China. linli@lzu.edu.cn
Chem Commun (Camb) ; 59(24): 3606-3609, 2023 Mar 21.
Article in En | MEDLINE | ID: mdl-36891781
ABSTRACT
The direct C2-addition of 5H-oxazol-4-ones to γ-keto-α,ß-unsaturated esters catalyzed by a chiral squaramide has been achieved. Diverse highly functionalized γ-keto esters bearing a C2-oxazolone at the α-position were afforded in high yields with excellent stereoselectivities (d.r. > 20 1 and up to 98% ee).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2023 Document type: Article