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Sex-specific effects of prenatal organophosphate ester (OPE) metabolite mixtures and adverse infant birth outcomes in the maternal and developmental risks from environmental and social stressors (MADRES) pregnancy cohort.
Hernandez-Castro, Ixel; Eckel, Sandrah P; Howe, Caitlin G; Niu, Zhongzheng; Kannan, Kurunthachalam; Robinson, Morgan; Foley, Helen B; Grubbs, Brendan; Al-Marayati, Laila; Lerner, Deborah; Lurvey, Nathana; Aung, Max T; Habre, Rima; Dunton, Genevieve F; Farzan, Shohreh F; Breton, Carrie V; Bastain, Theresa M.
Affiliation
  • Hernandez-Castro I; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Eckel SP; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Howe CG; Department of Epidemiology, Geisel School of Medicine at Dartmouth, New Hampshire, USA.
  • Niu Z; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Kannan K; Wadsworth Center, New York State Department of Health, Albany, NY, USA.
  • Robinson M; Wadsworth Center, New York State Department of Health, Albany, NY, USA.
  • Foley HB; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Grubbs B; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Al-Marayati L; Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Lerner D; Eisner Health, Los Angeles, CA, USA.
  • Lurvey N; Eisner Health, Los Angeles, CA, USA.
  • Aung MT; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Habre R; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Dunton GF; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
  • Farzan SF; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Breton CV; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Bastain TM; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: bastain@usc.edu.
Environ Res ; 226: 115703, 2023 06 01.
Article in En | MEDLINE | ID: mdl-36934865
ABSTRACT

BACKGROUND:

Organophosphate esters (OPEs) are used as flame retardants and plasticizers in various consumer products. Limited prior research suggests sex-specific effects of prenatal OPE exposures on fetal development. We evaluated overall and sex-specific associations between prenatal OPE exposures and gestational age (GA) at birth and birthweight for gestational age (BW for GA) z-scores among the predominately low-income, Hispanic MADRES cohort.

METHODS:

Nine OPE metabolite concentrations were measured in 421 maternal urine samples collected during a third trimester visit (GA = 31.5 ± 2.0 weeks). We examined associations between single urinary OPE metabolites and GA at birth and BW for GA z-scores using linear regression models and Generalized Additive Models (GAMs) and effects from OPE mixtures using Bayesian Kernel Machine Regression (BKMR). We also assessed sex-specific differences in single metabolite analyses by evaluating statistical interactions and stratifying by sex.

RESULTS:

We did not find significant associations between individual OPE metabolites and birth outcomes in the full infant sample; however, we found that higher bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) was associated with earlier GA at birth among male infants (p = 0.04), and a nonlinear, inverted U-shape association between the sum of dibutyl phosphate and di-isobutyl phosphate (DNBP + DIBP) and GA at birth among female infants (p = 0.03). In mixtures analysis, higher OPE metabolite mixture exposures was associated with lower GA at birth, which was primarily driven by female infants. No associations were observed between OPE mixtures and BW for GA z-scores.

CONCLUSION:

Higher BDCIPP and DNBP + DIBP concentrations were associated with earlier GA at birth among male and female infants, respectively. Higher exposure to OPE mixtures was associated with earlier GA at birth, particularly among female infants. However, we saw no associations between prenatal OPEs and BW for GA. Our results suggest sex-specific impacts of prenatal OPE exposures on GA at birth.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organophosphates / Flame Retardants Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Infant / Male / Newborn / Pregnancy Language: En Journal: Environ Res Year: 2023 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organophosphates / Flame Retardants Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Infant / Male / Newborn / Pregnancy Language: En Journal: Environ Res Year: 2023 Document type: Article Affiliation country: Estados Unidos