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Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 ß-Lactamase.
Tooke, Catherine L; Hinchliffe, Philip; Beer, Michael; Zinovjev, Kirill; Colenso, Charlotte K; Schofield, Christopher J; Mulholland, Adrian J; Spencer, James.
Affiliation
  • Tooke CL; School of Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom.
  • Hinchliffe P; School of Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom.
  • Beer M; School of Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom.
  • Zinovjev K; Centre for Computational Chemistry, School of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, United Kingdom.
  • Colenso CK; School of Biochemistry, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom.
  • Schofield CJ; Departamento de Química Física, Universitat de València, Burjassot 46100, Comunitat Valenciana, Spain.
  • Mulholland AJ; School of Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom.
  • Spencer J; Centre for Computational Chemistry, School of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, United Kingdom.
J Am Chem Soc ; 145(13): 7166-7180, 2023 04 05.
Article in En | MEDLINE | ID: mdl-36972204
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbapenems / Anti-Bacterial Agents Language: En Journal: J Am Chem Soc Year: 2023 Document type: Article Affiliation country: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbapenems / Anti-Bacterial Agents Language: En Journal: J Am Chem Soc Year: 2023 Document type: Article Affiliation country: Reino Unido