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Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil.
Finardi, Amanda Juliane; Oliveira, Nathan Guilherme de; Moraes, Eloise Brasil de; Batista, Lavínia Cássia Ferreira; Bortolomai, Bruna Eduarda; Suffys, Philip Noel; Baptista, Ida Maria Foschiani Dias.
Affiliation
  • Finardi AJ; Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
  • Oliveira NG; Universidade Estadual Paulista, Faculdade de Medicina, Botucatu, SP, Brasil.
  • Moraes EB; Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
  • Batista LCF; Universidade Estadual Paulista, Faculdade de Medicina, Botucatu, SP, Brasil.
  • Bortolomai BE; Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
  • Suffys PN; Universidade Estadual Paulista, Faculdade de Medicina, Botucatu, SP, Brasil.
  • Baptista IMFD; Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
Rev Soc Bras Med Trop ; 562023.
Article in En | MEDLINE | ID: mdl-36995787
ABSTRACT

BACKGROUND:

Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006.

METHODS:

We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state.

RESULTS:

The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity.

CONCLUSIONS:

A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leprosy / Mycobacterium leprae Type of study: Incidence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Rev Soc Bras Med Trop Year: 2023 Document type: Article Affiliation country: Brasil
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leprosy / Mycobacterium leprae Type of study: Incidence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Country/Region as subject: America do sul / Brasil Language: En Journal: Rev Soc Bras Med Trop Year: 2023 Document type: Article Affiliation country: Brasil