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Nav1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation.
Wimalasena, Nivanthika K; Taub, Daniel G; Shim, Jaehoon; Hakim, Sara; Kawaguchi, Riki; Chen, Lubin; El-Rifai, Mahmoud; Geschwind, Daniel H; Dib-Hajj, Sulayman D; Waxman, Stephen G; Woolf, Clifford J.
Affiliation
  • Wimalasena NK; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Taub DG; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Shim J; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Hakim S; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Kawaguchi R; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Chen L; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT 06516, USA.
  • El-Rifai M; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  • Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Dib-Hajj SD; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT 06516, USA.
  • Waxman SG; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT 06516, USA.
  • Woolf CJ; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: clifford.woolf@childrens.harvard.edu.
Exp Neurol ; 364: 114393, 2023 06.
Article in En | MEDLINE | ID: mdl-37003485
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NAV1.7 Voltage-Gated Sodium Channel / Gain of Function Mutation Limits: Animals Language: En Journal: Exp Neurol Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NAV1.7 Voltage-Gated Sodium Channel / Gain of Function Mutation Limits: Animals Language: En Journal: Exp Neurol Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos