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Roles of human cytochrome P450 3A4/5 in dexamethasone 6ß-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin.
Uehara, Shotaro; Shimizu, Makiko; Suemizu, Hiroshi; Yamazaki, Hiroshi.
Affiliation
  • Uehara S; Central Institute for Experimental Animals, Kawasaki-ku, Kawasaki, 210-0821, Japan.
  • Shimizu M; Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
  • Suemizu H; Central Institute for Experimental Animals, Kawasaki-ku, Kawasaki, 210-0821, Japan.
  • Yamazaki H; Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan. Electronic address: hyamazak@ac.shoyaku.ac.jp.
Drug Metab Pharmacokinet ; 50: 100504, 2023 Jun.
Article in En | MEDLINE | ID: mdl-37031476
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Cytochrome P-450 Enzyme System Limits: Animals / Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2023 Document type: Article Affiliation country: Japón
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Cytochrome P-450 Enzyme System Limits: Animals / Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2023 Document type: Article Affiliation country: Japón