Short, Lipidated Dendrimeric γ-AApeptides as New Antimicrobial Peptidomimetics.
Int J Mol Sci
; 24(7)2023 Mar 29.
Article
in En
| MEDLINE
| ID: mdl-37047380
ABSTRACT
Antibiotic resistance is one of the most significant issues encountered in global health. There is an urgent demand for the development of a new generation of antibiotic agents combating the emergence of drug resistance. In this article, we reported the design of lipidated dendrimeric γ-AApeptides as a new class of antimicrobial agents. These AApeptides showed excellent potency and broad-spectrum activity against both Gram-positive bacteria and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The mechanistic studies revealed that the dendrimeric AApeptides could kill bacteria rapidly through the permeabilization of bacterial membranes, analogous to host-defense peptides (HDPs). These dendrimers also did not induce antibiotic resistance readily. The easy access to the synthesis, together with their potent and broad-spectrum activity, make these lipidated dendrimeric γ-AApeptides a new generation of antibacterial agents.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Methicillin-Resistant Staphylococcus aureus
/
Peptidomimetics
/
Anti-Infective Agents
Language:
En
Journal:
Int J Mol Sci
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos