Preclinical safety assessment of photoluminescent metal quantum clusters stabilized with autologous serum proteins for host specific theranostics.
Nanotheranostics
; 7(3): 316-326, 2023.
Article
in En
| MEDLINE
| ID: mdl-37064608
ABSTRACT
Host derived serum proteome stabilised red-emitting gold quantum clusters (or Au-QC-NanoSera or QCNS) of size range ~2 nm have been synthesised in a first reported study. The host serum was taken from bovine, murine and human origins to establish the proof of concept. In-vitro biocompatibility with normal murine L929 fibroblast cells and radiosensitisation ability against PLC/PRF/5 hepatoma cells was established. A concentration dependant radiosensitisation effect of QCNS at differential γ-radiation doses was observed with almost 90% killing of cancer cells at a radiation dose of 5Gy. Acute and subacute safety, and non-immunogenicity of autologously derived QCNS was established in in-bred C57BL/6 mice. The biodistribution analysis revealed that the QCNS were effectively cleared from the body over a course of 28 days and were found to pose no major threat to the proper functioning and morphology of the mice.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Proteins
/
Precision Medicine
Limits:
Animals
/
Humans
Language:
En
Journal:
Nanotheranostics
Year:
2023
Document type:
Article
Affiliation country:
India
Publication country:
AU
/
AUSTRALIA
/
AUSTRÁLIA