Plasma Amyloid-ß Homeostasis Is Associated with Body Mass Index and Weight Loss in People with Overweight and Obesity.
J Alzheimers Dis
; 93(2): 653-664, 2023.
Article
in En
| MEDLINE
| ID: mdl-37066906
ABSTRACT
BACKGROUND:
Obesity is linked to a higher incidence of Alzheimer's disease (AD). Studies show that plasma amyloid-ß (Aß) dyshomeostasis, particularly low 42/40 ratio indicates a heightened risk for developing AD. However, the relationship between body mass index (BMI) and circulating plasma Aß has not been extensively studied.OBJECTIVE:
We hypothesized that people with a high BMI have altered plasma Aß homeostasis compared with people with a lower BMI. We also tested whether reducing BMI by calorie-restriction could normalize plasma concentrations of Aß.METHODS:
Plasma concentrations of Aß40, Aß42, and Aß42/40 ratio were measured in 106 participants with BMIs classified as lean, overweight, or obese. From this cohort, twelve participants with overweight or obese BMIs entered a 12-week calorie-restriction weight loss program. We then tested whether decreasing BMI affected plasma Aß concentrations.RESULTS:
Plasma Aß42/40 ratio was 17.54% lower in participants with an obese BMI compared to lean participants (pâ<â0.0001), and 11.76% lower compared to participants with an overweight BMI (pâ<â0.0001). The weight loss regimen decreased BMI by an average of 4.02% (pâ=â0.0005) and was associated with a 6.5% decrease in plasma Aß40 (pâ=â0.0425). However, weight loss showed negligible correlations with plasma Aß40, Aß42, and Aß42/40 ratio.CONCLUSION:
Obesity is associated with aberrant plasma Aß homeostasis which may be associated with an increased risk for AD. Weight loss appears to lower Aß40, but large-scale longitudinal studies in addition to molecular studies are required to elucidate the underlying mechanisms of how obesity and weight loss influence plasma Aß homeostasis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amyloid beta-Peptides
/
Overweight
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2023
Document type:
Article
Affiliation country:
Australia