Dapagliflozin induced hypernatremia via osmotic diuresis: a case report.
CEN Case Rep
; 13(1): 9-13, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-37074627
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been widely used. They inhibit proximal tubular glucose reabsorption, resulting in glycosuria. Herein, we report the case of a 65-year-old woman who presented with hypernatremia during the perioperative period of a subarachnoid hemorrhage. The patient continued to take dapagliflozin postoperatively and subsequently developed severe hypernatremia. Based on the urinalysis findings, we diagnosed osmotic diuresis due to glycosuria as contributing to hypernatremia. Hypernatremia improved with the discontinuation of dapagliflozin and the administration of a hypotonic infusion. In the perioperative period, physicians should discontinue SGLT2 inhibitors owing to concerns about the development of hypernatremia.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzhydryl Compounds
/
Glucosides
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Glycosuria
/
Hypernatremia
Limits:
Aged
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Female
/
Humans
Language:
En
Journal:
CEN Case Rep
Year:
2024
Document type:
Article
Affiliation country:
Japón
Country of publication:
Japón