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Dapagliflozin induced hypernatremia via osmotic diuresis: a case report.
Sugiyama, Juri; Ryuge, Akihiro; Mitsubayashi, Kenta; Ito, Masashi; Matsumoto, Naoki; Takeuchi, Riku; Azuma, Kiho; Hachiya, Asaka; Asano, Marina; Nakamura, Tomonobu.
Affiliation
  • Sugiyama J; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan.
  • Ryuge A; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan. ryuge0120@yahoo.co.jp.
  • Mitsubayashi K; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan.
  • Ito M; Department of Neurosurgery, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
  • Matsumoto N; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan.
  • Takeuchi R; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan.
  • Azuma K; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan.
  • Hachiya A; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan.
  • Asano M; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan.
  • Nakamura T; Department of Nephrology, National Hospital Organization Nagoya Medical Center, 1-1 Sannomaru, Naka-Ku, Nagoya, Aichi, 460-0001, Japan.
CEN Case Rep ; 13(1): 9-13, 2024 02.
Article in En | MEDLINE | ID: mdl-37074627
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been widely used. They inhibit proximal tubular glucose reabsorption, resulting in glycosuria. Herein, we report the case of a 65-year-old woman who presented with hypernatremia during the perioperative period of a subarachnoid hemorrhage. The patient continued to take dapagliflozin postoperatively and subsequently developed severe hypernatremia. Based on the urinalysis findings, we diagnosed osmotic diuresis due to glycosuria as contributing to hypernatremia. Hypernatremia improved with the discontinuation of dapagliflozin and the administration of a hypotonic infusion. In the perioperative period, physicians should discontinue SGLT2 inhibitors owing to concerns about the development of hypernatremia.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzhydryl Compounds / Glucosides / Glycosuria / Hypernatremia Limits: Aged / Female / Humans Language: En Journal: CEN Case Rep Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Japón

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzhydryl Compounds / Glucosides / Glycosuria / Hypernatremia Limits: Aged / Female / Humans Language: En Journal: CEN Case Rep Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Japón