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Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial.
Kelley, Robin Kate; Ueno, Makoto; Yoo, Changhoon; Finn, Richard S; Furuse, Junji; Ren, Zhenggang; Yau, Thomas; Klümpen, Heinz-Josef; Chan, Stephen L; Ozaka, Masato; Verslype, Chris; Bouattour, Mohamed; Park, Joon Oh; Barajas, Olga; Pelzer, Uwe; Valle, Juan W; Yu, Li; Malhotra, Usha; Siegel, Abby B; Edeline, Julien; Vogel, Arndt.
Affiliation
  • Kelley RK; Department of Medicine, Division of Hematology/Oncology, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.
  • Ueno M; Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan.
  • Yoo C; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Finn RS; Department of Medicine, Division of Hematology/Oncology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Furuse J; Department of Medical Oncology, Kyorin University Hospital, Tokyo, Japan.
  • Ren Z; Department of Hepatic Oncology, Liver Cancer Institute of Zhongshan Hospital, Fudan University, National Clinical Research Center for Interventional Medicine, Shanghai, China.
  • Yau T; Department of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Klümpen HJ; Department of Medical Oncology, Amsterdam University Medical Centers, Cancer Center Amsterdam, Amsterdam, Netherlands.
  • Chan SL; State Key Laboratory of Translational Oncology, Department of Clinical Oncology, Sir Yue-Kong Pao Center for Cancer, the Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Ozaka M; Department of Hepato-Biliary-Pancreatic Medicine, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.
  • Verslype C; Digestive Oncology, University Hospitals Leuven, Leuven, Belgium.
  • Bouattour M; Liver Cancer Unit, Hôpital Beaujon, Clichy, France.
  • Park JO; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Barajas O; Department of Medical Oncology, Arturo López Pérez Foundation, Santiago, Chile.
  • Pelzer U; Department of Hematology, Oncology and Cancer Immunology, Charite Campus Mitte, Freie Universität Berlin, Humboldt Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
  • Valle JW; Division of Cancer Sciences, University of Manchester and Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
  • Yu L; Biostatistics and Research Decision Sciences, Merck & Co, Rahway, NJ, USA.
  • Malhotra U; Global Clinical Development, Merck & Co, Rahway, NJ, USA.
  • Siegel AB; Global Clinical Development, Merck & Co, Rahway, NJ, USA.
  • Edeline J; INSERM, University Rennes, Department of Medical Oncology, CLCC Eugène Marquis, COSS (Chemistry Oncogenesis Signaling), Rennes, France.
  • Vogel A; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hanover, Germany. Electronic address: vogel.arndt@mh-hannover.de.
Lancet ; 401(10391): 1853-1865, 2023 06 03.
Article in En | MEDLINE | ID: mdl-37075781
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biliary Tract Neoplasms / Gemcitabine Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Lancet Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biliary Tract Neoplasms / Gemcitabine Type of study: Clinical_trials / Prognostic_studies Limits: Humans Language: En Journal: Lancet Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido