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Brain Activation Evoked by Motor Imagery in Pediatric Patients with Complete Spinal Cord Injury.
Wang, L; Zheng, W M; Liang, T F; Yang, Y H; Yang, B N; Chen, X; Chen, Q; Li, X J; Lu, J; Li, B W; Chen, N.
Affiliation
  • Wang L; From the Department of Radiology and Nuclear Medicine (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Zheng WM; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Beijing, China.
  • Liang TF; From the Department of Radiology and Nuclear Medicine (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Yang YH; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Beijing, China.
  • Yang BN; Department of Medical Imaging (T.F.L., B.W.L.), Affiliated Hospital of Hebei Engineering University, Handan, Hebei Province, China.
  • Chen X; From the Department of Radiology and Nuclear Medicine (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Chen Q; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Beijing, China.
  • Li XJ; From the Department of Radiology and Nuclear Medicine (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Lu J; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Beijing, China.
  • Li BW; From the Department of Radiology and Nuclear Medicine (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Chen N; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics (L.W., W.M.Z., Y.H.Y., B.N.Y., X.C., J.L., N.C.), Beijing, China.
AJNR Am J Neuroradiol ; 44(5): 611-617, 2023 05.
Article in En | MEDLINE | ID: mdl-37080724
ABSTRACT
BACKGROUND AND

PURPOSE:

Currently, there is no effective treatment for pediatric patients with complete spinal cord injury. Motor imagery has been proposed as an alternative to physical training for patients who are unable to move voluntarily. Our aim was to reveal the potential mechanism of motor imagery in the rehabilitation of pediatric complete spinal cord injury. MATERIALS AND

METHODS:

Twenty-six pediatric patients with complete spinal cord injury and 26 age- and sex-matched healthy children as healthy controls were recruited. All participants underwent the motor imagery task-related fMRI scans, and additional motor execution scans were performed only on healthy controls. First, we compared the brain-activation patterns between motor imagery and motor execution in healthy controls. Then, we compared the brain activation of motor imagery between the 2 groups and compared the brain activation of motor imagery in pediatric patients with complete spinal cord injury and that of motor execution in healthy controls.

RESULTS:

In healthy controls, compared with motor execution, motor imagery showed increased activation in the left inferior parietal lobule and decreased activation in the left supplementary motor area, paracentral lobule, middle cingulate cortex, and right insula. In addition, our results revealed that the 2 groups both activated the bilateral supplementary motor area, middle cingulate cortex and left inferior parietal lobule, and supramarginal gyrus during motor imagery. Compared with healthy controls, higher activation in the bilateral paracentral lobule, supplementary motor area, putamen, and cerebellar lobules III-V was detected in pediatric complete spinal cord injury during motor imagery, and the activation of these regions was even higher than that of healthy controls during motor execution.

CONCLUSIONS:

Our study demonstrated that part of the motor imagery network was functionally preserved in pediatric complete spinal cord injury and could be activated through motor imagery. In addition, higher-level activation in sensorimotor-related regions was also found in pediatric complete spinal cord injury during motor imagery. Our findings may provide a theoretic basis for the application of motor imagery training in pediatric complete spinal cord injury.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Brain Limits: Child / Humans Language: En Journal: AJNR Am J Neuroradiol Year: 2023 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord Injuries / Brain Limits: Child / Humans Language: En Journal: AJNR Am J Neuroradiol Year: 2023 Document type: Article Affiliation country: China