Metals and inorganic molecules in regulating protein and nucleic acid phase separation.
Curr Opin Chem Biol
; 74: 102308, 2023 06.
Article
in En
| MEDLINE
| ID: mdl-37088005
ABSTRACT
The realization that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells has motivated efforts to modulate the condensation process of biomolecules. Increasing evidence shows that metals and inorganic molecules abundantly distributed in cells play important roles in the regulation of biomolecular condensation. Herein, we briefly reviewed the background of biomacromolecular phase separation and summarized the recent research progress on the roles of metals and inorganic molecules in regulating protein and nucleic acid phase separation in vitro and in cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nucleic Acids
Language:
En
Journal:
Curr Opin Chem Biol
Journal subject:
BIOQUIMICA
Year:
2023
Document type:
Article