Your browser doesn't support javascript.
loading
Calcified Chondroid Mesenchymal Neoplasm: Exploring the Morphologic and Clinical Features of an Emergent Entity With a Series of 33 Cases.
Kallen, Michael E; Michal, Michael; Meyer, Anders; Suster, David I; Olson, Nicholas J; Charville, Gregory W; Perret, Raul; Gross, John M.
Affiliation
  • Kallen ME; Department of Pathology, University of Maryland School of Medicine.
  • Michal M; Biopticka Laboratory, Pilsen, Czech Republic.
  • Meyer A; Department of Pathology and Laboratory Medicine, University of Kansas School of Medicine, Kansas City, KS.
  • Suster DI; Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Rutgers, NJ.
  • Olson NJ; Physicians Laboratory.
  • Charville GW; University of South Dakota Sanford School of Medicine, Sioux Falls, SD.
  • Perret R; Department of Pathology, Stanford Medicine, Stanford, CA.
  • Gross JM; Institut Bergonié / Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Am J Surg Pathol ; 47(6): 725-737, 2023 06 01.
Article in En | MEDLINE | ID: mdl-37102574
ABSTRACT
Calcified chondroid mesenchymal neoplasm is a term proposed for tumors with a spectrum of morphologic features, including cartilage/chondroid matrix formation, that frequently harbor FN1 gene fusions. We report a series of 33 cases of putative calcified chondroid mesenchymal neoplasms, mostly referred for expert consultation out of concern for malignancy. Patients included 17 males and 16 females, with a mean age of 51.3 years. Anatomic locations include the hands and fingers, feet and toes, head and neck, and temporomandibular joint; 1 patient presented with multifocal disease. Radiologic review showed soft tissue masses with variable internal calcification, which occasionally scalloped bone but in all cases appeared indolent/benign. Tumors had a mean gross size of 2.1 cm and a homogenous rubbery to fibrous/gritty tan-white cut surface. Histology demonstrated multinodular architecture with a prominent chondroid matrix and increased cellularity towards the periphery of the nodules. The tumor cells were polygonal with eccentric nuclei and bland cytologic features and showed a variable amount of increased spindled / fibroblastic forms in the perinodular septa. The majority of cases had notable grungy and/or lacy calcifications. A subset of cases demonstrated at least focal areas of increased cellularity and osteoclast-like giant cells. Herein, we confirm the distinct morphologic and clinicopathologic features associated with this entity with the largest series to date, with a focus on practical diagnostic separation from similar chondroid neoplasms. Awareness of these features is critical in avoiding pitfalls, including a malignant diagnosis of chondrosarcoma.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Chondrosarcoma / Neoplasms, Connective and Soft Tissue Limits: Female / Humans / Male / Middle aged Language: En Journal: Am J Surg Pathol Year: 2023 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Chondrosarcoma / Neoplasms, Connective and Soft Tissue Limits: Female / Humans / Male / Middle aged Language: En Journal: Am J Surg Pathol Year: 2023 Document type: Article