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Stretchable ultrasonic arrays for the three-dimensional mapping of the modulus of deep tissue.
Hu, Hongjie; Ma, Yuxiang; Gao, Xiaoxiang; Song, Dawei; Li, Mohan; Huang, Hao; Qian, Xuejun; Wu, Ray; Shi, Keren; Ding, Hong; Lin, Muyang; Chen, Xiangjun; Zhao, Wenbo; Qi, Baiyan; Zhou, Sai; Chen, Ruimin; Gu, Yue; Chen, Yimu; Lei, Yusheng; Wang, Chonghe; Wang, Chunfeng; Tong, Yitian; Cui, Haotian; Abdal, Abdulhameed; Zhu, Yangzhi; Tian, Xinyu; Chen, Zhaoxin; Lu, Chengchangfeng; Yang, Xinyi; Mu, Jing; Lou, Zhiyuan; Eghtedari, Mohammad; Zhou, Qifa; Oberai, Assad; Xu, Sheng.
Affiliation
  • Hu H; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Ma Y; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Gao X; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Song D; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Li M; Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Huang H; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Qian X; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Wu R; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Shi K; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Ding H; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Lin M; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Chen X; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Zhao W; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Qi B; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Zhou S; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Chen R; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Gu Y; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Chen Y; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Lei Y; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Wang C; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Wang C; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Tong Y; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Cui H; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
  • Abdal A; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
  • Zhu Y; Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, CA, USA.
  • Tian X; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Chen Z; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Lu C; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Yang X; Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
  • Mu J; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Lou Z; Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
  • Eghtedari M; Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
  • Zhou Q; Department of Radiology, School of Medicine, University of California San Diego, La Jolla, CA, USA.
  • Oberai A; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  • Xu S; Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
Nat Biomed Eng ; 7(10): 1321-1334, 2023 Oct.
Article in En | MEDLINE | ID: mdl-37127710
ABSTRACT
Serial assessment of the biomechanical properties of tissues can be used to aid the early detection and management of pathophysiological conditions, to track the evolution of lesions and to evaluate the progress of rehabilitation. However, current methods are invasive, can be used only for short-term measurements, or have insufficient penetration depth or spatial resolution. Here we describe a stretchable ultrasonic array for performing serial non-invasive elastographic measurements of tissues up to 4 cm beneath the skin at a spatial resolution of 0.5 mm. The array conforms to human skin and acoustically couples with it, allowing for accurate elastographic imaging, which we validated via magnetic resonance elastography. We used the device to map three-dimensional distributions of the Young's modulus of tissues ex vivo, to detect microstructural damage in the muscles of volunteers before the onset of soreness and to monitor the dynamic recovery process of muscle injuries during physiotherapies. The technology may facilitate the diagnosis and treatment of diseases affecting tissue biomechanics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Screening_studies Language: En Journal: Nat Biomed Eng Year: 2023 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Screening_studies Language: En Journal: Nat Biomed Eng Year: 2023 Document type: Article Affiliation country: Estados Unidos