Chiral Graphene Quantum Dots Enhanced Drug Loading into Small Extracellular Vesicles.
ACS Nano
; 17(11): 10191-10205, 2023 06 13.
Article
in En
| MEDLINE
| ID: mdl-37127891
ABSTRACT
As nanoscale extracellular vesicles secreted by cells, small extracellular vesicles (sEVs) have enormous potential as safe and effective vehicles to deliver drugs into lesion locations. Despite promising advances with sEV-based drug delivery systems, there are still challenges to drug loading into sEVs, which hinder the clinical applications of sEVs. Herein, we report an exogenous drug-agnostic chiral graphene quantum dots (GQDs) sEV-loading platform, based on chirality matching with the sEV lipid bilayer. Both hydrophobic and hydrophilic chemical and biological drugs can be functionalized or adsorbed onto GQDs by π-π stacking and van der Waals interactions. By tuning the ligands and GQD size to optimize its chirality, we demonstrate drug loading efficiency of 66.3% and 64.1% for doxorubicin and siRNA, which is significantly higher than other reported sEV loading techniques.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quantum Dots
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Extracellular Vesicles
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Graphite
Language:
En
Journal:
ACS Nano
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos