Determination of the Re-188 Calibration Number for the Capintec CRC- 25PET Dose Calibrator.
Curr Radiopharm
; 16(4): 292-299, 2023.
Article
in En
| MEDLINE
| ID: mdl-37138431
BACKGROUND: During the development of novel Re-188 radiopharmaceuticals, it was discovered that no calibration settings were published to calibrate Re-188 on the Capintec CRC-25PET dose calibrator. METHODS: Sodium [188Re]perrhenate was eluted from an OncoBeta 188W/188Re generator to measure activity on a Capintec CRC-25R dose calibrator using established dose calibrator settings provided by the manufacturer. The eluent was then used to tune the calibra on settings on a Capintec CRC-25PET dose calibrator, accounting for geometry. Radionuclidic purity of the [188Re]perrhenate source was verified via gamma spectroscopy. RESULTS: The calibrator number for Re-188 was determined to be 469 x 10 for the Capintec CRC-25PET dose calibrator, which differed from the manufacturer provided calibra on number of 496 x 10 for the Capintec CRC-25R dose calibra on model. W-188 breakthrough was characterised as < 0.01%. CONCLUSION: This previously unreported calibration number can be used to determine the activity of Re- 188 labelled radiopharmaceuticals using the Capintec CRC-25PET dose calibrator model.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radioisotopes
/
Rhenium
Type of study:
Prognostic_studies
Language:
En
Journal:
Curr Radiopharm
Year:
2023
Document type:
Article
Affiliation country:
Australia
Country of publication:
Emiratos Árabes Unidos