Electrochemical aptasensor based on gold nanoparticle decorated Ti3C2Tx nanocomposites for chloramphenicol detection.
Mikrochim Acta
; 190(6): 206, 2023 05 10.
Article
in En
| MEDLINE
| ID: mdl-37162685
ABSTRACT
Using gold (Au) nanoparticle decorated Ti3C2Tx (Ti3C2Tx-Au) nanocomposites, a highly sensitive electrochemical aptasensor for the effective detection of chloramphenicol has been developed. As a two-dimensional layered material, the prepared composite not only provides high surface area, good conductivity, and thermal stability but also substantial binding sites for aptamers with high sensitivity and selectivity for the accurate determination of chloramphenicol. Interestingly, the conductivity and active sites were enhanced by freeze-drying Ti3C2Tx and in situ formation of Ti3C2Tx-Au nanocomposite. The fabricated aptasensor exhibited a very low detection limit (S/N ≥ 3) of 13.18 fg mL-1 with a linear range of 1 ~ 700 pg mL-1 and correlation coefficient of 0.9992. The fabricated aptasensor demonstrated an excellent reproducibility, repeatability, long-term stability, and high selectivity toward chloramphenicol. Further, the aptasensor was applied to real milk samples, and the recoveries were ranged from 98.93 to 101.93%.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biosensing Techniques
/
Aptamers, Nucleotide
/
Nanocomposites
/
Metal Nanoparticles
Type of study:
Diagnostic_studies
Language:
En
Journal:
Mikrochim Acta
Year:
2023
Document type:
Article
Affiliation country:
China