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Acidity-Triggered Charge-Convertible Conjugated Polymer for Dihydroartemisinin Delivery and Tumor-Specific Chemo-Photothermal Therapy.
Lu, Jingsong; Yu, Jing; Xie, Wensheng; Guo, Zhenhu; Gao, Xiaohan; Li, Ying; Zhang, Ziqing; Jin, Zeping; Fahad, Abdul; Che, Shenglei; Zhao, Lingyun; Wei, Yen.
Affiliation
  • Lu J; Department of Chemistry, Tsinghua University, Beijing 100084, China.
  • Yu J; State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
  • Xie W; Research Center of Magnetic and Electronic Materials, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Guo Z; Institute of Process Engineering Chinese Academy of Sciences, State Key Laboratories of Biochemical Engineering, Beijing 100190, China.
  • Gao X; Department of Neurosurgery, Yuquan Hospital School of Clinical Medicine, Tsinghua University, Beijing 100084, China.
  • Li Y; Department of Chemistry, Tsinghua University, Beijing 100084, China.
  • Zhang Z; State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
  • Jin Z; Research Center of Magnetic and Electronic Materials, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Fahad A; Institute of Process Engineering Chinese Academy of Sciences, State Key Laboratories of Biochemical Engineering, Beijing 100190, China.
  • Che S; Department of Neurosurgery, Yuquan Hospital School of Clinical Medicine, Tsinghua University, Beijing 100084, China.
  • Zhao L; Department of Chemistry, Tsinghua University, Beijing 100084, China.
  • Wei Y; State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
ACS Appl Bio Mater ; 6(6): 2303-2313, 2023 06 19.
Article in En | MEDLINE | ID: mdl-37190932
ABSTRACT
Since the nonspecificity and nonselectivity of traditional treatment models lead to the difficulty of cancer treatment, nanobased strategies are needed to fill in the gaps of current approaches. Herein, a tumor microenvironment (TME)-responsive chemo-photothermal treatment model was developed based on dihydroartemisinin (DHA)-loaded conjugated polymers (DHA@PLGA-PANI). The synthesized DHA@PLGA-PANI exhibited enhanced photothermal properties under mild-acidic conditions and thus triggered local heat at the tumor site. Meanwhile, these iron-doped conjugated polymers of PLGA-PANI were used as the source of Fe, and benefiting from the Fe-dependent cytotoxicity of DHA, the burst of free radicals could be generated in tumors. Therefore, the combination of TME-responsive chemo-photothermal therapy could achieve effective tumor efficacy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hyperthermia, Induced / Neoplasms Limits: Humans Language: En Journal: ACS Appl Bio Mater Year: 2023 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hyperthermia, Induced / Neoplasms Limits: Humans Language: En Journal: ACS Appl Bio Mater Year: 2023 Document type: Article Affiliation country: China