Anti-cocaine Vaccine Development: Where Are We Now and Where Are We Going?
J Med Chem
; 66(11): 7086-7100, 2023 06 08.
Article
in En
| MEDLINE
| ID: mdl-37227096
ABSTRACT
Cocaine is one of the oldest and most widely used illicit drugs in the world and is responsible for major worldwide medical and social problems. Drug addiction is a disease state where the body relies on a substance for normal functioning and develops a physical dependence leading to compulsive and repetitive use despite negative consequences to the user's health, mental state, or social life. The primary driver for the development of anti-cocaine vaccines has been the failure to develop effective pharmacological treatments to combat cocaine dependence. Despite several decades of research, no approved pharmacological treatments for cocaine dependence are available to assist addicts to overcome cocaine withdrawal or to prevent drug relapse. This Perspective highlights the challenges associated with anti-cocaine vaccines, including the current state of anti-cocaine vaccines and catalytic antibody research to aid in the fight against cocaine addiction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Substance Withdrawal Syndrome
/
Vaccines
/
Cocaine
/
Substance-Related Disorders
/
Cocaine-Related Disorders
Limits:
Humans
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2023
Document type:
Article
Affiliation country:
Australia