Reduction of systemic exposure and side effects by intra-articular injection of anti-inflammatory agents for osteoarthritis: what is the safer strategy?

Xie, Zuoxu; Wang, Lu; Chen, Jie; Zheng, Zicong; Srinual, Songpol; Guo, Annie; Sun, Rongjin; Hu, Ming

Xie, Zuoxu; Wang, Lu; Chen, Jie; Zheng, Zicong; Srinual, Songpol; Guo, Annie; Sun, Rongjin; Hu, Ming.

Affiliation

Xie Z; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.
Wang L; Drug Metabolism and Pharmacokinetics, Biogen, Cambridge, MA, USA.
Chen J; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.
Zheng Z; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.
Srinual S; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.
Guo A; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.
Sun R; Drug Metabolism and Pharmacokinetics, Biogen, Cambridge, MA, USA.
Hu M; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA.

J Drug Target ; 31(6): 596-611, 2023 07.

Article in En | MEDLINE | ID: mdl-37249274

Subject(s)
Key words

Osteoarthritis; anti-inflammatory drugs; local bioavailability; locally active drugs; pharmacokinetics; systemic and local side effect

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis Limits: Humans Language: En Journal: J Drug Target Journal subject: FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido

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