Wnt/ß-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer.

ABSTRACT

The Wnt/ß-catenin signaling pathway is a growth control pathway involved in various biological processes as well as the development and progression of cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. The hyperactivation of Wnt signaling is observed in almost all CRC and plays a crucial role in cancer-related processes such as cancer stem cell (CSC) propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss how the Wnt/ß-catenin signaling pathway is involved in the carcinogenesis and progression of CRC and related therapeutic approaches.