Mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with age-related hearing loss.
FEBS Open Bio
; 13(7): 1365-1374, 2023 07.
Article
in En
| MEDLINE
| ID: mdl-37258461
ABSTRACT
Previous studies have revealed that age-related hearing loss (AHL) in Cdk5 regulatory subunit-associated protein 1 (Cdk5rap1)-knockout mice is associated with pathology in the cochlea. Here, we aimed to identify mitochondrial alterations in the cochlea of Cdk5rap1-knockout mice with AHL. Mitochondria in the spiral ganglion neurons (SGNs) and hair cells (HCs) were normal despite senescence; however, the mitochondria of types I, II, and IV spiral ligament fibrocytes were ballooned, damaged, and ballooned, respectively, in the stria vascularis. Our results suggest that the accumulation of dysfunctional mitochondria in the lateral wall, rather than the loss of HCs and SGNs, leads to the onset of AHL. Our results provide valuable information regarding the underlying mechanisms of AHL and the relationship between aberrant tRNA modification-induced hearing loss and mitochondrial dysfunction.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cochlea
/
Hearing Loss
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
FEBS Open Bio
Year:
2023
Document type:
Article
Affiliation country:
Japón