Application of Metagenomic High-Throughput Sequencing in a Rare Case of Multisite Infection With Two Microorganisms After Total Knee Arthroplasty.
Orthopedics
; 47(1): e52-e56, 2024.
Article
in En
| MEDLINE
| ID: mdl-37276443
ABSTRACT
Postoperative deep infection is usually identified by microbial culture. However, frequent false-negative results have severely limited effective treatment. We report a rare case of intra-articular and paravertebral infection after total knee arthroplasty caused by Mycoplasma hominis and Ureaplasma urealyticum, with multiple negative microbial culture results. Eventually, the pathogens were identified using metagenomic high-throughput sequencing, and the patient was successfully treated with several "old" antibiotics. We analyze the clinical characteristics of this patient and systematically describe the application of high-throughput sequencing and antibiotics. [Orthopedics. 2024;47(1)e52-e56.].
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ureaplasma Infections
/
Arthroplasty, Replacement, Knee
/
Mycoplasma Infections
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Orthopedics
Year:
2024
Document type:
Article