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Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition.
Cazzoli, Riccardo; Romeo, Francesco; Pallavicini, Isabella; Peri, Sebastiano; Romanenghi, Mauro; Pérez-Valencia, Juan Alberto; Hagag, Eman; Ferrucci, Filippo; Elgendy, Mohamed; Vittorio, Orazio; Pece, Salvatore; Foiani, Marco; Westermarck, Jukka; Minucci, Saverio.
Affiliation
  • Cazzoli R; Department of Experimental Oncology, IEO IRCCS, Istituto Europeo di Oncologia, Milan, Italy.
  • Romeo F; Department of Experimental Oncology, IEO IRCCS, Istituto Europeo di Oncologia, Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
  • Pallavicini I; Department of Experimental Oncology, IEO IRCCS, Istituto Europeo di Oncologia, Milan, Italy.
  • Peri S; Department of Experimental Oncology, IEO IRCCS, Istituto Europeo di Oncologia, Milan, Italy.
  • Romanenghi M; Department of Experimental Oncology, IEO IRCCS, Istituto Europeo di Oncologia, Milan, Italy.
  • Pérez-Valencia JA; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Mildred-Scheel Early Career Center, Nati
  • Hagag E; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Ferrucci F; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Mildred-Scheel Early Career Center, Nati
  • Elgendy M; Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Medical Clinic I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Mildred-Scheel Early Career Center, Nati
  • Vittorio O; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Randwick, NSW, Australia; School of Biomedical Sciences, UNSW Sydney, Randwick, NSW, Australia.
  • Pece S; Department of Experimental Oncology, IEO IRCCS, Istituto Europeo di Oncologia, Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
  • Foiani M; IFOM (Fondazione Istituto FIRC di Oncologia Molecolare), Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.
  • Westermarck J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland.
  • Minucci S; Department of Experimental Oncology, IEO IRCCS, Istituto Europeo di Oncologia, Milan, Italy; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy. Electronic address: saverio.minucci@ieo.it.
Cell Rep ; 42(6): 112616, 2023 06 27.
Article in En | MEDLINE | ID: mdl-37289585
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Electron Transport Complex I / Chaperone-Mediated Autophagy / Neoplasms Limits: Humans Language: En Journal: Cell Rep Year: 2023 Document type: Article Affiliation country: Italia
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Electron Transport Complex I / Chaperone-Mediated Autophagy / Neoplasms Limits: Humans Language: En Journal: Cell Rep Year: 2023 Document type: Article Affiliation country: Italia