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CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in preclinical breast cancer model.
Gupta, Nikita; Mohan, Chakrabhavi Dhananjaya; Shanmugam, Muthu K; Jung, Young Yun; Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali; Ashrafizadeh, Milad; Mahale, Manas; Bender, Andreas; Kumar, Alan Prem; Putti, Thomas Choudary; Rangappa, Kanchugarakoppal S; Zhang, Xianbin; Ahn, Kwang Seok; Sethi, Gautam.
Affiliation
  • Gupta N; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address: nikitag@u.nus.edu.
  • Mohan CD; Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, 570006, India [Present address: FEST Division CSIR-Indian Institute of Toxicology Research Vishvigyan Bhawan 31, Mahatma Gandhi Marg Lucknow - 226 001 Uttar Pradesh, India].
  • Shanmugam MK; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
  • Jung YY; Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea.
  • Chinnathambi A; Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia.
  • Alharbi SA; Department of Botany and Microbiology, College of Science, King Saud University, PO Box -2455, Riyadh, 11451, Saudi Arabia.
  • Ashrafizadeh M; Department of General Surgery and Institute of Precision Diagnosis and Treatment of Digestive System Tumors, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, 518055, China.
  • Mahale M; Department of Pharmaceutical Chemistry, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai, 400 098, India.
  • Bender A; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom.
  • Kumar AP; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore.
  • Putti TC; Department of Pathology, National University of Singapore, National University Hospital, Kent Ridge Road, Singapore, 119074, Singapore.
  • Rangappa KS; Institution of Excellence, Vijnana Bhavan, University of Mysore, Manasagangotri, Mysore, 570006, India.
  • Zhang X; Department of General Surgery and Institute of Precision Diagnosis and Treatment of Digestive System Tumors, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, 518055, China.
  • Ahn KS; Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea. Electronic address: ksahn@khu.ac.kr.
  • Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address: phcgs@nus.edu.sg.
Environ Res ; 232: 116335, 2023 Sep 01.
Article in En | MEDLINE | ID: mdl-37290620
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnenediones / Triple Negative Breast Neoplasms / Liver Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Environ Res Year: 2023 Document type: Article Country of publication: Países Bajos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnenediones / Triple Negative Breast Neoplasms / Liver Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Environ Res Year: 2023 Document type: Article Country of publication: Países Bajos