Chimaeric plant-produced bluetongue virus particles as potential vaccine candidates.
Arch Virol
; 168(7): 179, 2023 Jun 13.
Article
in En
| MEDLINE
| ID: mdl-37310539
ABSTRACT
Bluetongue virus (BTV) causes bluetongue disease in ruminants and sheep. The current live attenuated and inactivated vaccines available for prevention pose several risks, and there is thus a need for vaccines that are safer, economically viable, and effective against multiple circulating serotypes. This work describes the development of recombinant virus-like particle (VLP) vaccine candidates in plants, which are assembled by co-expression of the four BTV serotype 8 major structural proteins. We show that substitution of a neutralising tip domain of BTV8 VP2 with that of BTV1 VP2 resulted in the assembly of VLPs that stimulated serotype-specific antibodies as well as virus-specific neutralising antibodies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bluetongue
/
Bluetongue virus
/
Vaccines, Virus-Like Particle
Limits:
Animals
Language:
En
Journal:
Arch Virol
Year:
2023
Document type:
Article
Affiliation country:
Sudáfrica