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Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes.
Nishi, Kiyoto; Yoshii, Akira; Abell, Lauren; Zhou, Bo; Frausto, Ricardo; Ritterhoff, Julia; McMillen, Timothy S; Sweet, Ian; Wang, Yibin; Gao, Chen; Tian, Rong.
Affiliation
  • Nishi K; Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA; Department of Pharmacology, Shiga University of Medical Science, Otsu, Shiga 520-2182, Japan.
  • Yoshii A; Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.
  • Abell L; Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.
  • Zhou B; Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.
  • Frausto R; Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Ritterhoff J; Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.
  • McMillen TS; Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA.
  • Sweet I; University of Washington Medicine Diabetes Institute, University of Washington, 750 Republican Street, Seattle, WA 98109, USA.
  • Wang Y; Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Signature Program in Cardiovascular and Metabolic Diseases, Duke-NUS School of Medicine, Singapore, Singapore.
  • Gao C; Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267-0575, USA. Ele
  • Tian R; Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA. Electronic address: rongtian@uw.edu.
Cell Rep ; 42(6): 112641, 2023 06 27.
Article in En | MEDLINE | ID: mdl-37310861
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocarboxylic Acid Transporters / Keto Acids Limits: Animals Language: En Journal: Cell Rep Year: 2023 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monocarboxylic Acid Transporters / Keto Acids Limits: Animals Language: En Journal: Cell Rep Year: 2023 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos