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Positive Progesterone Receptor Expression in Meningioma May Increase the Transverse Relaxation: First Prospective Clinical Trial Using Single-Shot Ultrafast T2 Mapping.
Li, Zongye; Wang, Xiao; Zhang, Hongyan; Yang, Yijie; Zhang, Yue; Zhuang, Yuchuan; Yang, Qinqin; Gao, Eryuan; Ren, Yanan; Zhang, Yong; Cai, Shuhui; Chen, Zhong; Cai, Congbo; Dong, Yanbo; Bao, Jianfeng; Cheng, Jingliang.
Affiliation
  • Li Z; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.).
  • Wang X; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.).
  • Zhang H; Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China (H.Z.).
  • Yang Y; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, China (Y.Y., Q.Y., S.C., Z.C., C.C.).
  • Zhang Y; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.).
  • Zhuang Y; Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York (Y.Z.).
  • Yang Q; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, China (Y.Y., Q.Y., S.C., Z.C., C.C.).
  • Gao E; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.).
  • Ren Y; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.).
  • Zhang Y; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.).
  • Cai S; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, China (Y.Y., Q.Y., S.C., Z.C., C.C.).
  • Chen Z; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, China (Y.Y., Q.Y., S.C., Z.C., C.C.).
  • Cai C; Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, Xiamen University, Xiamen, China (Y.Y., Q.Y., S.C., Z.C., C.C.).
  • Dong Y; Institute of Psychology, Herzen State Pedagogical University of Russia, Saint Petersburg, Russia (Y.D.).
  • Bao J; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.).
  • Cheng J; Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou 450000, China (Z.L., X.W., Y.Z., E.G., Y.R., Y.Z., J.B., J.C.). Electronic address: fccchengjl@zzu.edu.cn.
Acad Radiol ; 31(1): 187-198, 2024 Jan.
Article in En | MEDLINE | ID: mdl-37316368
ABSTRACT
RATIONALE AND

OBJECTIVES:

This project aims to investigate the diagnostic performance of multiple overlapping-echo detachment imaging (MOLED) technique-derived transverse relaxation time (T2) maps in predicting progesterone receptor (PR) and S100 expression in meningiomas. MATERIALS AND

METHODS:

63 meningioma patients were enrolled from October 2021 to August 2022, who underwent a complete routine magnetic resonance imaging and T2 MOLED, which can characterize the whole brain transverse relaxation time within 32 seconds in a single scan. After the surgical resection of meningiomas, the expression levels of PR and S100 were determined by an experienced pathologist using immunohistochemistry techniques. Histogram analysis was performed in tumor parenchyma based on the parametric maps. Independent t test and Mann-Whitney U test were applied for the comparison of histogram parameters between different groups, with a significance level of P < .05. Logistic regression and receiver operating characteristic (ROC) analysis with 95% confidence interval were conducted for the diagnostic efficiency evaluation.

RESULTS:

PR-positive group had significantly elevated T2 histogram parameters (P = .001-.049) compared to the PR-negative group. The multivariate logistic regression model with T2 showed the highest area under the ROC curve (AUC) for predicting PR expression (AUC=0.818). Additionally, the multivariate model also had the best diagnostic performance for predicting meningioma S100 expression (AUC=0.768).

CONCLUSION:

The MOLED technique-derived T2 maps can distinguish PR and S100 status in meningiomas preoperatively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Meningeal Neoplasms / Meningioma Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Acad Radiol Journal subject: RADIOLOGIA Year: 2024 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Meningeal Neoplasms / Meningioma Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Acad Radiol Journal subject: RADIOLOGIA Year: 2024 Document type: Article