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Exploring the potential of microRNA as a diagnostic tool for gestational diabetes.
Elhag, Duaa Ahmed; Al Khodor, Souhaila.
Affiliation
  • Elhag DA; Maternal and Child Health Division, Research Branch, Sidra Medicine, Doha, Qatar.
  • Al Khodor S; Maternal and Child Health Division, Research Branch, Sidra Medicine, Doha, Qatar. salkhodor@sidra.org.
J Transl Med ; 21(1): 392, 2023 06 17.
Article in En | MEDLINE | ID: mdl-37330548
ABSTRACT
MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. Recent studies have indicated a role of miRNAs in the pathogenesis of gestational diabetes mellitus (GDM), a common pregnancy-related disorder characterized by impaired glucose metabolism. Aberrant expression of miRNAs has been observed in the placenta and/or maternal blood of GDM patients, suggesting their potential use as biomarkers for early diagnosis and prognosis. Additionally, several miRNAs have been shown to modulate key signaling pathways involved in glucose homeostasis, insulin sensitivity, and inflammation, providing insights into the pathophysiology of GDM. This review summarizes the current knowledge on the dynamics of miRNA in pregnancy, their role in GDM as well as their potential as diagnostic and therapeutic targets.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications / Insulin Resistance / Diabetes, Gestational / MicroRNAs Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Female / Humans / Pregnancy Language: En Journal: J Transl Med Year: 2023 Document type: Article Affiliation country: Qatar

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications / Insulin Resistance / Diabetes, Gestational / MicroRNAs Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Female / Humans / Pregnancy Language: En Journal: J Transl Med Year: 2023 Document type: Article Affiliation country: Qatar