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Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype.
Matsudaira, Tatsuyuki; Nakano, Sosuke; Konishi, Yusuke; Kawamoto, Shimpei; Uemura, Ken; Kondo, Tamae; Sakurai, Koki; Ozawa, Takaaki; Hikida, Takatoshi; Komine, Okiru; Yamanaka, Koji; Fujita, Yuki; Yamashita, Toshihide; Matsumoto, Tomonori; Hara, Eiji.
Affiliation
  • Matsudaira T; Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. matsudaira@biken.osaka-u.ac.jp.
  • Nakano S; Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Konishi Y; Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Kawamoto S; Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Uemura K; Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Kondo T; Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Sakurai K; Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Ozawa T; Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Hikida T; Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Komine O; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
  • Yamanaka K; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.
  • Fujita Y; Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Yamashita T; Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Matsumoto T; Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Hara E; Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. ehara@biken.osaka-u.ac.jp.
Commun Biol ; 6(1): 665, 2023 06 23.
Article in En | MEDLINE | ID: mdl-37353538
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microglia / White Matter Limits: Animals Language: En Journal: Commun Biol Year: 2023 Document type: Article Affiliation country: Japón Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microglia / White Matter Limits: Animals Language: En Journal: Commun Biol Year: 2023 Document type: Article Affiliation country: Japón Country of publication: Reino Unido