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Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria.
Marco, Alicia; Vigueras, Gloria; Busto, Natalia; Cutillas, Natalia; Bautista, Delia; Ruiz, José.
Affiliation
  • Marco A; Departamento de Química Inorgánica, Universidad de Murcia, and Biomedical Research Institute of Murcia (IMIB-Arrixaca), E-30100 Murcia, Spain. jruiz@um.es.
  • Vigueras G; Departamento de Química Inorgánica, Universidad de Murcia, and Biomedical Research Institute of Murcia (IMIB-Arrixaca), E-30100 Murcia, Spain. jruiz@um.es.
  • Busto N; Departamento de Química, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001, Burgos, Spain. nbusto@ubu.es.
  • Cutillas N; Departamento de Ciencias de la Salud. Facultad de Ciencias de la Salud. Universidad de Burgos, Hospital Militar, Paseo de los Comendadores, s/n, 09001 Burgos, Spain.
  • Bautista D; Departamento de Química Inorgánica, Universidad de Murcia, and Biomedical Research Institute of Murcia (IMIB-Arrixaca), E-30100 Murcia, Spain. jruiz@um.es.
  • Ruiz J; SUIC-ACTI, Universidad de Murcia, E-30100 Murcia, Spain.
Dalton Trans ; 52(38): 13482-13486, 2023 Oct 03.
Article in En | MEDLINE | ID: mdl-37358044
ABSTRACT
New valproate Ir(III) and Rh(III) half-sandwich conjugates containing a C,N-phenylbenzimidazole chelated ligand have been synthesized and characterized. The valproic acid conjugation to organometallic fragments seems to switch on the antibacterial activity of the complexes towards Enterococcus faecium and Staphylococcus aureus Gram-positive bacteria.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhodium / Valproic Acid Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: España
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhodium / Valproic Acid Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2023 Document type: Article Affiliation country: España