Association of Ureaplasma infection pattern and azithromycin treatment effect with bronchopulmonary dysplasia in Ureaplasma positive infants: a cohort study.
BMC Pulm Med
; 23(1): 229, 2023 Jun 26.
Article
in En
| MEDLINE
| ID: mdl-37365524
ABSTRACT
BACKGROUND:
It is unclear whether Ureaplasma-associated pneumonia and azithromycin treatment affect the risk for bronchopulmonary dysplasia (BPD).METHODS:
A retrospective cohort study was performed in very low birth weight (VLBW) infants who tested positive for Ureaplasma within 72 h after birth in a tertiary unit. Chest X-ray (CXR) and laboratory test were performed before and after azithromycin treatment. Multivariate logistic regression analysis was used to identify the independent association between BPD and Ureaplasma-associated pneumonia, as well as BPD and effective azithromycin treatment.RESULTS:
A total of 118 infants were included in the current study, of whom 36 developed BPD (defined as supplemental oxygen needed at postmenstrual age 36 weeks or discharge). The rate of BPD was significantly higher in infants with Ureaplasma-associated pneumonia (44.6%) compared to infants with Ureaplasma colonization (17.7%, P = 0.002). After adjusting for confounders, an effective azithromycin treatment was significantly associated with reduced risk of BPD [odd ratio (OR) 0.011; 95% confidence interval (CI) 0.000-0.250), whereas Ureaplasma-associated pneumonia was not significantly associated with BPD (OR 1.835; 95% CI 0.548-6.147).CONCLUSION:
Effective Azithromycin treatment in Ureaplasma positive VLBW infants was associated with a reduced risk of BPD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bronchopulmonary Dysplasia
/
Ureaplasma Infections
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Infant
/
Newborn
Language:
En
Journal:
BMC Pulm Med
Year:
2023
Document type:
Article
Affiliation country:
China