Multi-Institutional Patterns of Use of Tumor-Treating Fields for Patients with Malignant Pleural Mesothelioma.
Curr Oncol
; 30(6): 5195-5200, 2023 05 23.
Article
in En
| MEDLINE
| ID: mdl-37366877
ABSTRACT
(1) Background:
The objective of this analysis was to evaluate the device usage rates and patterns of use regarding Tumor-Treating Fields (TTFields) for patients with malignant pleural mesothelioma (MPM) throughout the US. (2)Methods:
We evaluated de-identified data from 33 patients with MPM enrolled in FDA-required HDE protocols at 14 institutions across the US from September 2019 to March 2022. (3)Results:
The median number of total TTFields usage days was 72 (range 6-649 days), and the total treatment duration was 160 months for all patients. A low usage rate (defined as less than 6 h per day, 25%) was observed in 34 (21.2%) months. The median TTFields usage in the first 3 months was 12 h per day (range 1.9-21.6 h), representing 50% (range 8-90%) of the potential daily duration. The median TTFields usage after 3 months decreased to 9.1 h per day (range 3.1-17 h), representing 38% (range 13-71%) of the daily duration, and was lower than usage in the first 3 months (p = 0.01). (4)Conclusions:
This study represents the first multicenter analysis of real-world TTFields usage based on usage patterns for MPM patients in clinical practice. The real-world usage level was lower than the suggested daily usage. Further initiatives and guidelines should be developed to evaluate the impact of this finding on tumor control.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mesothelioma, Malignant
/
Neoplasms
Type of study:
Clinical_trials
/
Guideline
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Curr Oncol
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos