[Incidence of chronic obstructive pulmonary disease and risk factors in the Suzhou cohort].
Zhonghua Liu Xing Bing Xue Za Zhi
; 44(6): 868-876, 2023 Jun 10.
Article
in Zh
| MEDLINE
| ID: mdl-37380406
ABSTRACT
Objective:
To understand the incidence of chronic obstructive pulmonary disease (COPD) in the Suzhou cohort, and explore the risk factors for the development of COPD in Suzhou, and provide a scientific basis for COPD prevention.Methods:
This study was based on the China Kadoorie Biobank project in Wuzhong District, Suzhou. After excluding individuals with airflow obstruction and self-reported chronic bronchitis, emphysema, or pulmonary heart disease at baseline, 45 484 individuals were finally included in the analysis. Cox proportional risk models were used to analyze risk factors of COPD and calculate hazard ratios and 95% confidence interval (CI) in the Suzhou cohort. The effect modifications of smoking on the association between other risk factors and COPD were evaluated.Results:
Complete follow-up was available through December 31, 2017. Participants were followed up for a median of 11.12 years, and 524 individuals were diagnosed with COPD during the follow-up period; the incidence was 105.54 per 100 000 person-years. Multivariate Cox proportional risk regression models showed that age (HR=3.78, 95%CI3.32-4.30), former smoking (HR=2.00, 95%CI1.24-3.22), current smoking (<10 cigarettes/day, HR=2.14, 95%CI1.36-3.35;≥10 cigarettes/day, HR=2.69, 95%CI1.60-4.54), history of respiratory disease (HR=2.08, 95%CI1.33-3.26), daily sleep duration ≥10 hours (HR=1.41, 95%CI1.02-1.95) were associated with increased risk of COPD. However, education level of primary school and above (primary or junior high school, HR=0.65, 95%CI0.52-0.81; high school and above, HR=0.54, 95%CI0.33-0.87), consuming fresh fruit daily (HR=0.59, 95%CI0.42-0.83) and consuming spicy food weekly (HR=0.71, 95%CI0.53-0.94) were associated with reduced risk of COPD.Conclusions:
The incidence of COPD is low in Suzhou. Older age, smoking, history of respiratory disease, and long sleep duration were risk factors for the development of COPD in the Suzhou cohort.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pulmonary Disease, Chronic Obstructive
Type of study:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Liu Xing Bing Xue Za Zhi
Year:
2023
Document type:
Article
Affiliation country:
China