Severe acute propoxyphene overdose: plasma concentrations of propoxyphene and norpropoxyphene and the effect of dopamine on circulatory failure.
Acta Anaesthesiol Scand
; 30(4): 271-6, 1986 May.
Article
in En
| MEDLINE
| ID: mdl-3739586
ABSTRACT
Twelve patients with cardiovascular failure because of propoxyphene self-poisoning were treated with dopamine. The patients responded favourably to dopamine infusion (2-17 micrograms/kg/min) with a dose-dependent rise in systolic arterial blood pressure and a fall in central venous pressure and copious urinary output. Side effects during infusion were few, and in periods where dopamine infusion exceeded 10 micrograms/kg/min no tachyarrhythmias were seen. Eleven of the patients were treated on a respirator. Two patients were discharged from the ICU with signs of hypoxic brain damage, one of whom recovered completely after 2 weeks. Serum propoxyphene and norpropoxyphene were measured in nine patients. All but one patient had either propoxyphene or norpropoxyphene concentrations above 3 mumol/l.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dextropropoxyphene
/
Cardiovascular Diseases
/
Dopamine
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Acta Anaesthesiol Scand
Year:
1986
Document type:
Article