[Regulation and influence of mitochondria on macrophages during hepatitis B virus infection].
Zhonghua Gan Zang Bing Za Zhi
; 31(6): 649-652, 2023 Jun 20.
Article
in Zh
| MEDLINE
| ID: mdl-37400393
ABSTRACT
Hepatitis B virus (HBV) infection is an important public health concern, as approximately 3.5% of the world's population is currently chronically infected. Chronic HBV infection is the primary cause of cirrhosis, hepatocellular carcinoma, and deaths related to liver disease globally. Studies have found that in HBV infection, viruses can directly or indirectly regulate mitochondrial energy metabolism, oxidative stress, respiratory chain metabolites, and autophagy, thereby altering macrophage activation status, differentiation types, and related cytokine secretion type and quantity regulations. Therefore, mitochondria have become an important signal source for macrophages to participate in the body's immune system during HBV infection, providing a basis for mitochondria to be considered as a potential therapeutic target for chronic hepatitis B.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hepatitis B, Chronic
/
Hepatitis B
/
Liver Neoplasms
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Gan Zang Bing Za Zhi
Journal subject:
GASTROENTEROLOGIA
Year:
2023
Document type:
Article
Affiliation country:
China