Meningeal regulation of infections: A double-edged sword.
Eur J Immunol
; 53(9): e2250267, 2023 09.
Article
in En
| MEDLINE
| ID: mdl-37402972
ABSTRACT
In the past 10 years, important discoveries have been made in the field of neuroimmunology, especially regarding brain borders. Indeed, meninges are protective envelopes surrounding the CNS and are currently in the spotlight, with multiple studies showing their involvement in brain infection and cognitive disorders. In this review, we describe the meningeal layers and their protective role in the CNS against bacterial, viral, fungal, and parasitic infections, by immune and nonimmune cells. Moreover, we discuss the neurological and cognitive consequences resulting from meningeal infections in neonates (e.g. infection with group B Streptococcus, cytomegalovirus,
) or adults (e.g. infection with Trypanosoma brucei, Streptococcus pneumoniae,
). We hope that this review will bring to light an integrated view of meningeal immune regulations during CNS infections and their neurological consequences.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Central Nervous System Infections
/
Meninges
Limits:
Adult
/
Humans
/
Newborn
Language:
En
Journal:
Eur J Immunol
Year:
2023
Document type:
Article
Affiliation country:
Francia