High-throughput screen with the l,d-transpeptidase Ldt<sub>Mt2</sub> of <i>Mycobacterium tuberculosis</i> reveals novel classes of covalently reacting inhibitors.

de Munnik, Mariska; Lang, Pauline A; De Dios Anton, Francisco; Cacho, Mónica; Bates, Robert H; Brem, Jürgen; Rodríguez Miquel, Beatriz; Schofield, Christopher J

High-throughput screen with the l,d-transpeptidase Ldt_Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.

de Munnik, Mariska; Lang, Pauline A; De Dios Anton, Francisco; Cacho, Mónica; Bates, Robert H; Brem, Jürgen; Rodríguez Miquel, Beatriz; Schofield, Christopher J.

Affiliation

de Munnik M; Chemistry Research Laboratory, Department of Chemistry, the Ineos Oxford Institute of Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk.
Lang PA; Chemistry Research Laboratory, Department of Chemistry, the Ineos Oxford Institute of Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk.
De Dios Anton F; Tres Cantos Medicines Development Campus, GlaxoSmithKline Calle Severo Ochoa 2, Tres Cantos Madrid Spain beatriz.rodriguez@gsk.com.
Cacho M; Tres Cantos Medicines Development Campus, GlaxoSmithKline Calle Severo Ochoa 2, Tres Cantos Madrid Spain beatriz.rodriguez@gsk.com.
Bates RH; Tres Cantos Medicines Development Campus, GlaxoSmithKline Calle Severo Ochoa 2, Tres Cantos Madrid Spain beatriz.rodriguez@gsk.com.
Brem J; Chemistry Research Laboratory, Department of Chemistry, the Ineos Oxford Institute of Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk.
Rodríguez Miquel B; Tres Cantos Medicines Development Campus, GlaxoSmithKline Calle Severo Ochoa 2, Tres Cantos Madrid Spain beatriz.rodriguez@gsk.com.
Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, the Ineos Oxford Institute of Antimicrobial Research, University of Oxford 12 Mansfield Road Oxford OX1 3TA UK christopher.schofield@chem.ox.ac.uk.

Chem Sci ; 14(26): 7262-7278, 2023 Jul 05.

Article in En | MEDLINE | ID: mdl-37416715

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Sci Year: 2023 Document type: Article Country of publication: Reino Unido

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Sci Year: 2023 Document type: Article Country of publication: Reino Unido