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Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models.
Hartl, Natascha; Gabold, Bettina; Adams, Friederike; Uhl, Philipp; Oerter, Sabrina; Gätzner, Sabine; Metzger, Marco; König, Ann-Christine; Hauck, Stefanie M; Appelt-Menzel, Antje; Mier, Walter; Fricker, Gert; Merkel, Olivia M.
Affiliation
  • Hartl N; Ludwig-Maximilians-University, Pharmaceutical Technology and Biopharmaceutics, Butenandtstr. 5-13, 81377, Munich, Germany.
  • Gabold B; Ludwig-Maximilians-University, Pharmaceutical Technology and Biopharmaceutics, Butenandtstr. 5-13, 81377, Munich, Germany.
  • Adams F; University of Stuttgart, Institute of Polymer Chemistry, Macromolecular Materials and Fiber Chemistry, Pfaffenwaldring 55, 70569 Stuttgart, Germany.
  • Uhl P; University Hospital Heidelberg, Department of Nuclear Medicine, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
  • Oerter S; Fraunhofer Institute for Silicate Research (ISC), Translational Center Regenerative Therapies (TLC-RT), 97070 Würzburg, Germany; University Hospital Würzburg, Chair of Tissue Engineering and Regenerative Medicine (TERM), 97070 Würzburg, Germany.
  • Gätzner S; Fraunhofer Institute for Silicate Research (ISC), Translational Center Regenerative Therapies (TLC-RT), 97070 Würzburg, Germany.
  • Metzger M; Fraunhofer Institute for Silicate Research (ISC), Translational Center Regenerative Therapies (TLC-RT), 97070 Würzburg, Germany; University Hospital Würzburg, Chair of Tissue Engineering and Regenerative Medicine (TERM), 97070 Würzburg, Germany.
  • König AC; Helmholtz Centrum Munich - German Research Center for Environmental Health, Research Unit Protein Science, Heidemannsstr. 1, 80939, Munich, Germany.
  • Hauck SM; Helmholtz Centrum Munich - German Research Center for Environmental Health, Research Unit Protein Science, Heidemannsstr. 1, 80939, Munich, Germany.
  • Appelt-Menzel A; Fraunhofer Institute for Silicate Research (ISC), Translational Center Regenerative Therapies (TLC-RT), 97070 Würzburg, Germany; University Hospital Würzburg, Chair of Tissue Engineering and Regenerative Medicine (TERM), 97070 Würzburg, Germany.
  • Mier W; University Hospital Heidelberg, Department of Nuclear Medicine, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.
  • Fricker G; University of Heidelberg, Institute for Pharmacy & Molekular Biotechnology, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany.
  • Merkel OM; Ludwig-Maximilians-University, Pharmaceutical Technology and Biopharmaceutics, Butenandtstr. 5-13, 81377, Munich, Germany. Electronic address: olivia.merkel@lmu.de.
J Control Release ; 360: 613-629, 2023 08.
Article in En | MEDLINE | ID: mdl-37437848
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethyleneimine / Induced Pluripotent Stem Cells Type of study: Prognostic_studies / Risk_factors_studies Aspects: Implementation_research Limits: Animals / Humans Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethyleneimine / Induced Pluripotent Stem Cells Type of study: Prognostic_studies / Risk_factors_studies Aspects: Implementation_research Limits: Animals / Humans Language: En Journal: J Control Release Journal subject: FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Alemania