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Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infection.
Chang, Hao-Chun; Chang, Che-Hao; Tien, Kuei-Lien; Tai, Chih-Hsun; Lin, Li-Min; Lee, Tai-Fen; Ku, Shih-Chi; Fang, Chi-Tai; Chen, Yee-Chun; Sheng, Wang-Huei.
Affiliation
  • Chang HC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hsin-Chu Branch, Biomedical Park Hospital, Hsin-Chu County, Taiwan.
  • Chang CH; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Taiwan.
  • Tien KL; Infection Control Center, National Taiwan University Hospital, Taipei City, Taiwan.
  • Tai CH; Department of Pharmacy, National Taiwan University Hospital, Taipei City, Taiwan.
  • Lin LM; Department of Nursing, National Taiwan University Hospital, Taipei City, Taiwan.
  • Lee TF; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
  • Ku SC; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
  • Fang CT; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Taiwan; Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
  • Chen YC; Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; School of Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan.
  • Sheng WH; Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; School of Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan. Electronic address: whsheng@ntu.edu.tw.
J Formos Med Assoc ; 123(1): 123-132, 2024 Jan.
Article in En | MEDLINE | ID: mdl-37451958
BACKGROUND: Coronavirus disease 2019 (COVID-19) has caused great impact on healthcare systems, including antibiotic usage and multi-drug resistant (MDR) bacterial infections at hospitals. We aim to investigate the trends of antimicrobial resistance among the major pathogens causing healthcare-associated infection (HAI) at intensive care units (ICU). MATERIAL AND METHODS: The demographic characteristics of hospitalization, usage of antimicrobial agents, counted by half-an-year DID (defined daily dose per 1000 patient-days), and HAI density of five major MDR bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Klebsiella pneumoniae (CRKP), and carbapenem-resistant Pseudomonas aeruginosa (CRPA), of ICU patients at a medical center in Taiwan during January 2017 to December 2021 were collected and analyzed. RESULTS: The total antibiotic usage, counted by DID, had a significant increasing trend, before COVID-19 occurrence in 2017-2019, but no further increase during the pandemic period in 2020-2021. However, comparing the two time periods, antibiotics consumption was significantly increased during pandemic period. There was no significant change of HAI density in MRSA, VRE, CRAB, CRKP, and CRPA, comparing the pandemic to the pre-pandemic period. Although, CRKP and CRPA infection rates were increasing during the pre-pandemic period, there was no further increase of CRKP and CRPA HAI rates during the pandemic period. CONCLUSION: During COVID-19 pandemic, there was no significant increase in HAI density of five major MDR bacteria at ICU in Taiwan, despite increased antibiotic usage. Strict infection prevention measures for COVID-19 precautions and sustained antimicrobial stewardship probably bring these effects.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cross Infection / Methicillin-Resistant Staphylococcus aureus / COVID-19 / Anti-Infective Agents Type of study: Risk_factors_studies Limits: Humans Language: En Journal: J Formos Med Assoc Journal subject: MEDICINA Year: 2024 Document type: Article Affiliation country: Taiwán Country of publication: Singapur

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cross Infection / Methicillin-Resistant Staphylococcus aureus / COVID-19 / Anti-Infective Agents Type of study: Risk_factors_studies Limits: Humans Language: En Journal: J Formos Med Assoc Journal subject: MEDICINA Year: 2024 Document type: Article Affiliation country: Taiwán Country of publication: Singapur