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Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer.
Babic, Ana; Rosenthal, Michael H; Sundaresan, Tilak K; Khalaf, Natalia; Lee, Valerie; Brais, Lauren K; Loftus, Maureen; Caplan, Leah; Denning, Sarah; Gurung, Anamol; Harrod, Joanna; Schawkat, Khoschy; Yuan, Chen; Wang, Qiao-Li; Lee, Alice A; Biller, Leah H; Yurgelun, Matthew B; Ng, Kimmie; Nowak, Jonathan A; Aguirre, Andrew J; Bhatia, Sangeeta N; Vander Heiden, Matthew G; Van Den Eeden, Stephen K; Caan, Bette J; Wolpin, Brian M.
Affiliation
  • Babic A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Rosenthal MH; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Sundaresan TK; Kaiser Permanente San Francisco, San Francisco, CA, USA.
  • Khalaf N; Center for Innovations in Quality, Effectiveness, and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center; Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
  • Lee V; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
  • Brais LK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Loftus M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Caplan L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Denning S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Gurung A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Harrod J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Schawkat K; Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Yuan C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Wang QL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Lee AA; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  • Biller LH; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Yurgelun MB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Ng K; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Nowak JA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Aguirre AJ; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Bhatia SN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Vander Heiden MG; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Van Den Eeden SK; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Caan BJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Wolpin BM; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nat Commun ; 14(1): 4317, 2023 07 18.
Article in En | MEDLINE | ID: mdl-37463915
ABSTRACT
Patients with pancreatic cancer commonly develop weight loss and muscle wasting. Whether adipose tissue and skeletal muscle losses begin before diagnosis and the potential utility of such losses for earlier cancer detection are not well understood. We quantify skeletal muscle and adipose tissue areas from computed tomography (CT) imaging obtained 2 months to 5 years before cancer diagnosis in 714 pancreatic cancer cases and 1748 matched controls. Adipose tissue loss is identified up to 6 months, and skeletal muscle wasting is identified up to 18 months before the clinical diagnosis of pancreatic cancer and is not present in the matched control population. Tissue losses are of similar magnitude in cases diagnosed with localized compared with metastatic disease and are not correlated with at-diagnosis circulating levels of CA19-9. Skeletal muscle wasting occurs in the 1-2 years before pancreatic cancer diagnosis and may signal an upcoming diagnosis of pancreatic cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Body Composition Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Body Composition Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Estados Unidos