Antibacterial metabolites from the beetle-associated fungus Penicillium chrysogenum.
An Acad Bras Cienc
; 95(suppl 1): e20220178, 2023.
Article
in En
| MEDLINE
| ID: mdl-37466533
ABSTRACT
The antibacterial secondary metabolites of the fungus Penicillium chrysogenum associated with the beetle Aspongopus chinensis were investigated through chromatographic fractionation methods of ethyl acetate extracts of the fungal cultures. Five compounds were isolated, and their structures were determined as emodin, 4-(methoxymethyl)benzoic acid, isoochracinic acid, secalonic acid D, and dicerandrol A using mass spectroscopy and nuclear magnetic resonance spectroscopic analyses. Emodin exhibited strong antimicrobial activity, especially against Staphylococcus aureus even when growing on cooked pork, with a minimal inhibitory concentration (MIC) of 6.3 µg/mL. Dimeric tetrahydroxanthones, such as secalonic acid D and dicerandrol A, also exhibited potent activity, with MIC values ranging from 9.5 to 28.5 µg/mL. In summary, P. chrysogenum was isolated as a symbiotic fungus of the beetle A. chinensis for the first time and this strain could generate antibacterial secondary metabolites, which could potently inhibit gram-positive bacteria growth in vitro.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Penicillium
/
Penicillium chrysogenum
/
Coleoptera
/
Emodin
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
An Acad Bras Cienc
Year:
2023
Document type:
Article
Affiliation country:
China