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Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Lax, Brianna M; Palmeri, Joseph R; Lutz, Emi A; Sheen, Allison; Stinson, Jordan A; Duhamel, Lauren; Santollani, Luciano; Kennedy, Alan; Rothschilds, Adrienne M; Spranger, Stefani; Sansom, David M; Wittrup, K Dane.
Affiliation
  • Lax BM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Palmeri JR; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Lutz EA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Sheen A; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Stinson JA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Duhamel L; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Santollani L; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Kennedy A; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Rothschilds AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Spranger S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Sansom DM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Wittrup KD; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Proc Natl Acad Sci U S A ; 120(31): e2300895120, 2023 08.
Article in En | MEDLINE | ID: mdl-37487077
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / Neoplasms Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2023 Document type: Article Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Regulatory / Neoplasms Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2023 Document type: Article Country of publication: Estados Unidos