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Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering.
Li, Li; Mohanty, Vakul; Dou, Jinzhuang; Huang, Yuefan; Banerjee, Pinaki P; Miao, Qi; Lohr, Jens G; Vijaykumar, Tushara; Frede, Julia; Knoechel, Birgit; Muniz-Feliciano, Luis; Laskowski, Tamara J; Liang, Shaoheng; Moyes, Judy S; Nandivada, Vandana; Basar, Rafet; Kaplan, Mecit; Daher, May; Liu, Enli; Li, Ye; Acharya, Sunil; Lin, Paul; Shanley, Mayra; Rafei, Hind; Marin, David; Mielke, Stephan; Champlin, Richard E; Shpall, Elizabeth J; Chen, Ken; Rezvani, Katayoun.
Affiliation
  • Li L; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Mohanty V; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Dou J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Huang Y; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Banerjee PP; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Miao Q; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lohr JG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Vijaykumar T; Harvard Medical School, Boston, MA, USA.
  • Frede J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Knoechel B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Muniz-Feliciano L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Laskowski TJ; Harvard Medical School, Boston, MA, USA.
  • Liang S; Harvard Medical School, Boston, MA, USA.
  • Moyes JS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Nandivada V; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Basar R; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kaplan M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Daher M; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Liu E; Department of Computer Science, Rice University, Houston, TX, USA.
  • Li Y; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Acharya S; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lin P; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Shanley M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Rafei H; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Marin D; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Mielke S; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Champlin RE; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Shpall EJ; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Chen K; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Rezvani K; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sci Adv ; 9(30): eadd6997, 2023 07 28.
Article in En | MEDLINE | ID: mdl-37494448
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Chimeric Antigen Type of study: Prognostic_studies Limits: Humans Language: En Journal: Sci Adv Year: 2023 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Chimeric Antigen Type of study: Prognostic_studies Limits: Humans Language: En Journal: Sci Adv Year: 2023 Document type: Article Affiliation country: Estados Unidos