The molecular genetics of anterior segment dysgenesis.
Exp Eye Res
; 234: 109603, 2023 09.
Article
in En
| MEDLINE
| ID: mdl-37495069
ABSTRACT
Anterior segment dysgenesis is a severe developmental eye disorder that leads to blindness in children. The exact mechanisms underlying this condition remain elusive. Recently, an increasing amount of studies have focused on genes and signal transduction pathways that affect anterior segment dysgenesis;these factors include transcription factors, developmental regulators, extracellular matrix genes, membrane-related proteins, cytoskeleton proteins and other associated genes. To date, dozens of gene variants have been found to cause anterior segment dysgenesis. However, there is still a lack of effective treatments. With a broader and deeper understanding of the molecular mechanisms underlying anterior segment development in the future, gene editing technology and stem cell technology may be new treatments for anterior segment dysgenesis. Further studies on the mechanisms of how different genes influence the onset and progression of anterior segment dysgenesis are still needed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Eye Abnormalities
/
Anterior Eye Segment
Limits:
Child
/
Humans
Language:
En
Journal:
Exp Eye Res
Year:
2023
Document type:
Article
Affiliation country:
China