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Integrin ß3 directly inhibits the Gα13-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis.
Zhang, Yaping; Zhao, Xiaojuan; Shen, Bo; Bai, Yanyan; Chang, Claire; Stojanovic, Aleksandra; Wang, Can; Mack, Andrew; Deng, Gary; Skidgel, Randal A; Cheng, Ni; Du, Xiaoping.
Affiliation
  • Zhang Y; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Zhao X; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Shen B; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Bai Y; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Chang C; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Stojanovic A; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Wang C; Dupage Medical Technology, Inc., Chicago, IL, 60612, USA.
  • Mack A; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Deng G; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
  • Skidgel RA; Eli Lilly, Indianapolis, IN, 46285, USA.
  • Cheng N; Dupage Medical Technology, Inc., Chicago, IL, 60612, USA.
  • Du X; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Nat Commun ; 14(1): 4966, 2023 08 16.
Article in En | MEDLINE | ID: mdl-37587112
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / GTP-Binding Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / GTP-Binding Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido