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Automated production of 11 C-labeled carboxylic acids and esters via "in-loop" 11 C-carbonylation using GE FX synthesis modules.
Kaur, Tanpreet; Wright, Jay S; Henderson, Bradford D; Godinez, Jonathan; Shao, Xia; Scott, Peter J H.
Affiliation
  • Kaur T; Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Wright JS; Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Henderson BD; Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Godinez J; Interdepartmental Program in Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
  • Shao X; Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Scott PJH; Division of Nuclear Medicine, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
J Labelled Comp Radiopharm ; 2023 Aug 22.
Article in En | MEDLINE | ID: mdl-37608567
ABSTRACT
An in-loop 11 C-carbonylation process for the radiosynthesis of 11 C-carboxylic acids and esters from halide precursors has been developed. The reaction proceeds at room temperature under mild conditions and enables 11 C-carbonylation of both electron deficient and electron rich (hetero)aromatic halides to provide 11 C-carboxylic acids and esters in good to excellent radiochemical yields, high radiochemical purity, and excellent molar activity. The process has been fully automated using commercial radiochemistry synthesis modules, and application to clinical production is demonstrated via validated cGMP radiosyntheses of [11 C]bexarotene and [11 C]acetoacetic acid.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Labelled Comp Radiopharm Year: 2023 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Labelled Comp Radiopharm Year: 2023 Document type: Article Affiliation country: Estados Unidos