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Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.
Voronkova, Maria A; Hansen, Heather L; Cooper, Madison P; Miller, Jacob; Sukumar, Narayanasami; Geldenhuys, Werner J; Robart, Aaron R; Webb, Bradley A.
Affiliation
  • Voronkova MA; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, U.S.A.
  • Hansen HL; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, U.S.A.
  • Cooper MP; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, U.S.A.
  • Miller J; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, U.S.A.
  • Sukumar N; Northeastern Collaborative Access Team Center for Advanced Macromolecular Crystallography, Argonne National Laboratory, Lemont, IL 60439, U.S.A.
  • Geldenhuys WJ; Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26506, U.S.A.
  • Robart AR; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, U.S.A.
  • Webb BA; Department of Biochemistry, West Virginia University School of Medicine, Morgantown, WV 26506, U.S.A.
Biochem J ; 480(17): 1411-1427, 2023 09 13.
Article in En | MEDLINE | ID: mdl-37622331
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphofructokinase-1 / Neoplasms Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Biochem J Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphofructokinase-1 / Neoplasms Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Biochem J Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido